Difference Between Amniocentesis and Chorionic Villus Sampling l Amniocentesis vs Chorionic Villus Sampling

The key difference between amniocentesis and chorionic villus sampling is that in amniocentesis, a small amount of amniotic fluid is taken for testing while in chorionic villus sampling, a small sample of the placenta is taken for testing.

Amniocentesis and Chorionic Villus Sampling are two prenatal diagnostic procedures that determine certain fetal genetic abnormalities. These tests reveal the genetic defects during the pregnancy. When there is a higher risk for genetic defects, doctors will order the chorionic villus sampling while when there is relatively a low risk, they order to perform an amniocentesis. Both tests are safe but, chorionic villus test has a slightly higher risk of miscarriage than amniocentesis. Furthermore, chorionic villus test can be performed little earlier than amniocentesis. A pregnant woman may consider either chorionic villus sampling or amniocentesis during the occasions such as having a high risk screening test for Down syndrome, having an experience of genetic defects during the previous pregnancy, having one or more relatives affected with a genetic disorder, having a scan showing certain abnormal ultrasound features or to make sure her baby has genetic defects, etc.


1. Overview and Key Difference
2. What is Amniocentesis
3. What is Chorionic Villus Sampling
4. Similarities Between Amniocentesis and Chorionic Villus Sampling
5. Side by Side Comparison – Amniocentesis vs Chorionic Villus Sampling in Tabular Form
6. Summary

What is Amniocentesis?

Amniocentesis is a prenatal diagnostic test that performs to determine chromosomal abnormalities in the fetus. When there is a relatively low risk of genetic defects, doctors may order to perform this test since it has a small risk for mother and the baby.

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