Difference Between Biochemical and Cell Based Assays | Biochemical vs Cell Based Assays

The key difference between biochemical and cell based assays is that the biochemical assays are target-based assays while cell based assays are physiology-based assays.

Assays are important in research and development of drugs. It is an investigative procedure in the fields of pharmacology, laboratory medicine, and molecular biology for quantitative measurement and qualitative assessment of the presence, quantity, and functional activity of a targeted entity. Hence, biochemical assays and cell-based assays are two types of assays which are used in drug development. Biochemical assays are important in detection and quantification of biological molecules with respect to their activity. On the other hand, cell based assays are important to obtain biologically relevant information to predict and identify the level of response of an organism for a particular substance/drug.


1. Overview and Key Difference
2. What are Biochemical Assays
3. What are Cell Based Assays
4. Similarities Between Biochemical and Cell Based Assays
5. Side by Side Comparison – Biochemical vs Cell Based Assays in Tabular Form
6. Summary