Difference Between Lamellipodia and Filopodia | Lamellipodia vs Filopodia

The key difference between lamellipodia and filopodia is that the lamellipodia are cytoskeletal actin projections present in the mobile edges of the cells while filopodia are thin cytoplasmic protrusions that extend from the leading edge of the mobile cells.

Lamellipodia and filopodia are two cellular extensions commonly used in cell probing and migration. These structures sense the extracellular conditions and locomote respectively. Hence, they are essential structures for cell mobility. Also, microspikes refer to these lamellipodia and filopodia, and compose actin filaments. Both structures are present on the leading edge of a migrating cell.


1. Overview and Key Difference
2. What is Lamellipodia 
3. What is Filopodia
4. Similarities Between Lamellipodia and Filopodia
5. Side by Side Comparison – Lamellipodia vs Filopodia in Tabular Form
6. Summary

What are Lamellipodia?

Lamellipodia are cytoskeleton protrusions in the flat ribbon-shape and present at the periphery of a migrating cell. These protrusions are enriched with a branched network of bi-dimensional dendric array of actin filaments. In other terms, a lamellipodium contains a two-dimensional actin mesh which propels the whole cellular structure across a substrate. Therefore, they are extremely vital for cell migration.