Difference Between Reductive Amination and Transamination l Reductive Amination vs Transamination

The key difference between reductive amination and transamination is that the reductive amination is the conversion of a carbonyl group into an amine group whereas the transamination is the transfer of an amine group from one molecule to another.

Amination is the process that we can use to introduce an amine group to a molecule. The reductive amination and transamination are two forms of amination processes. Therefore, these processes also involve in the introduction of an amine group to a molecule, but in different pathways; reductive amination involves the conversion of an existing group into an amine group whereas transamination involves the transferring of an amine group.


1. Overview and Key Difference
2. What is Reductive Amination
3. What is Transamination
4. Side by Side Comparison – Reductive Amination vs Transamination in Tabular Form
5. Summary

What is Reductive Amination?

Reductive amination is a form of amination process in which we convert a carbonyl group into an amine group. We call it “reductive alkylation” as well. This process undergoes through an imine. The carbonyl groups that can involve in these reactions are aldehyde or ketone groups mainly. Moreover, it is one the most efficient ways of amination. Therefore, most industries use this process.